Deregulation of Cdt1 induces chromosomal damage without rereplication and leads to chromosomal instability
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چکیده
منابع مشابه
Deregulation of Cdt1 induces chromosomal damage without rereplication and leads to chromosomal instability.
The activity of human Cdt1 is negatively regulated by multiple mechanisms. This suggests that Cdt1 deregulation may have a deleterious effect. Indeed, it has been suggested that overexpression of Cdt1 can induce rereplication in cancer cells and that rereplication activates Ataxia-telangiectasia-mutated (ATM) kinase and/or ATM- and Rad3-related (ATR) kinase-dependent checkpoint pathways. In thi...
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ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2006
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.03031